I have about 45 users using a published remoteapp without any issue except for one user. On her workstation, if I login as her, and I double click on a published remoteapp, nothing happens. I look at the RDP file setup and it is correct. When logged in to that same workstation as a different user and launch the same RDP file, it starts up the remote application no problem. So could not be the RDP file. If I login as her on that workstation, and start mstsc.exe, I get the Remote Desktop Connection and is able to connect to the TS and run the application that way. With the RDP file however, I can't even right click on it and edit or do anything. It just acts like I did not click anything.
Not sure what I am missing. This just happen last week. Before that, everything was working fine until a Windows update. Rolling back the update did not help however. The OS is Windows 10 and 2008 R2 for the TS server.