Setup
I have Server 2016 set up with Remote desktop Services. Its primary function is to deploy one particular application, installed on the server, with RemoteApp. The Configuration for the workstations is being pushed out with a GPO, and RemoteApp shortcuts are successfully being placed in the Start Menu. We have approximately 50 Users utilizing this application, and for 95% of them this works perfectly.
Issue
While running the application on one monitor (right), under certain circumstances, the application will jump to the second monitor, maximize, and "appear" to be frozen (no response to mouse movements). We have a remote control software used for troubleshooting. When we shadow the console on the users workstation, you can clearly see the application is open on the second monitor (left). When we shadow the users' session on the server, the application appears to be maximized on the right. Restoring the window restores the window to the right monitor, both on the workstation console (jumps) and server session, and regains control.
Attempted Resolutions
We have attempted video driver updates, alternate graphics adapters, complete windows updates, restoring older versions of mstsc.exe (for Windows 10 1803 users, per another hotfix), and switching primary monitors and resolutions. The problem still arises. Problem only exists for particular users for dual screens. User A and User B have identical hardware and dal screens, but problem only exists for User A. User C has a different make & model desktop, and User D has a laptop with a docking station, and both C & D experience the same issue. We cannot duplicate the issue on workstations that aren't experiencing it already.